Consumption of nattokinase was associated with a reduction in both systolic and diastolic BP. The reduction in systolic BP was seen for both sexes but was more robust in males consuming nattokinase.

The average reduction in diastolic BP in the nattokinase group from 87 mmHg to 84 mmHg was statistically significant when compared to that in the group consuming placebo, where the average diastolic BP remained constant at 87 mmHg (P<0.05), and reached a high level of significance for males consuming nattokinase, where the average diastolic BP dropped from 86 mmHg to 81 mmHg (P<0.006). A decrease in vWF was seen in the female population consuming nattokinase (P<0.1).

In the subpopulation with low plasma renin activity levels at baseline (<0.29 ng/mL/h), an increase was seen for 66% of the people after 8-week consumption of nattokinase (P<0.1), in contrast to only 8% in the placebo group.

Author information:

Jensen GS, Lenninger M, Ero MP, Benson KF.

  • NIS Labs, Klamath Falls, OR.
  • Machaon Diagnostics, Inc., Oakland, CA, USA.


Integr Blood Press Control. 2016 Oct 13;9:95-104. eCollection 2016.


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Consumption Of Nattokinase Is Associated With Reduced Blood Pressure & von Willebrand Factor, A Cardiovascular Risk Marker: Results From A Randomized, Double-blind, Placebo-controlled, Multicenter North American Clinical Trial. was last modified: December 12th, 2016 by Guo Loong Ng